Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (ME/CFS) Viral Research
The site lists studies focusing on the role of viral infection in chronic fatigue syndrome / myalgic encephalomyelitis (ME/CFS), and lists studies examining antivirals and immunomodulators as potential treatments for ME/CFS.
ME/CFS has been linked to specific enteroviruses (namely coxsackievirus B and echovirus), specific herpesviruses (namely Epstein-Barr virus, cytomegalovirus, HHV-6, HHV-7 and varicella zoster virus), as well as parvovirus B19, and the bacterium Chlamydia pneumoniae.
Studies focusing on the role of enterovirus in ME/CFS
Some history and background context for these enterovirus studies can be found in this MEpedia article.
A
study of Coxsackie B virus infections, 1972-1983
Alpha-Interferon
treatment of patients with chronic fatigue syndrome
Amplification
and identification of enteroviral sequences in the postviral fatigue syndrome
An
Outbreak of Encephalomyelitis in the Royal Free Hospital Group, London, in 1955
An
outbreak of encephalomyelitis in the Royal Free Hospital Group, London, in 1955
Antibody
to Coxsackie B virus in diagnosing postviral fatigue syndrome
Chronic
Enterovirus Infection In Patients With Postviral Fatigue Syndrome
Chronic
fatigue syndrome: clinical condition associated with immune activation
Closeness
of Contacts Between People in Two Clusters of Chronic Fatigue Syndrome: Evidence for an Infectious Etiology?
Comparison
of Coxsackie B neutralization and enteroviral PCR in chronic fatigue patients
Coxsackie
B infection in a general medical unit
Coxsackie
B infection in a Scottish general practice
Coxsackie
B viruses and myalgic encephalomyelitis
Detection
of Enterovirus in Human Skeletal Muscle From Patients With Chronic Inflammatory Muscle Disease or Fibromyalgia and
Healthy Subjects
Detection
of enterovirus-specific RNA in serum: the relationship to chronic fatigue
Encephalomyelitis
Resembling Benign Myalgic Encephalomyelitis
Enteroviral
RNA sequences detected by polymerase chain reaction in muscle of patients with postviral fatigue syndrome
Enterovirus
in the Chronic Fatigue Syndrome
Enterovirus
related metabolic myopathy: a postviral fatigue syndrome
Enterovirus
Related Myopathy in a Subset of Chronic Fatigue Syndrome?
Enteroviruses
and postviral fatigue syndrome
Enteroviruses
and the Chronic Fatigue Syndrome
Enteroviruses in chronic fatigue syndrome: "now you see them, now you don't"
Epidemiological
Aspects Of An Outbreak Of Encephalomyelitis At The Royal Free Hospital, London, In The Summer Of 1955
Evidence
for enteroviral persistence in humans
Interferon-alpha
therapy for patients with chronic fatigue syndrome
Investigation
by polymerase chain reaction of enteroviral infection in patients with chronic fatigue syndrome
Monospot
and VP1 tests in chronic fatigue syndrome and major depression
Myalgic
encephalomyelitis - a persistent enteroviral infection?
Myalgic
encephalomyelitis - report of an epidemic
No
Findings of Enteroviruses in Swedish Patients with Chronic Fatigue Syndrome
Persistence
of enteroviral RNA in chronic fatigue syndrome is associated with the abnormal production of equal amounts of
positive and negative strands of enteroviral RNA
Persistence
of enterovirus RNA in muscle biopsy samples suggests that some cases of chronic fatigue syndrome result from a
previous, inflammatory viral myopathy
Persistent
virus infection of muscle in postviral fatigue syndrome
Phylogenetic
analysis of short enteroviral sequences from patients with chronic fatigue syndrome
Postviral
fatigue syndrome: persistence of enterovirus RNA in muscle and elevated creatine kinase
Prevalence
in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects
Simultaneous
Measurement of Antibodies to Epstein-Barr Virus, Human Herpesvirus 6, Herpes Simplex Virus Types 1 and 2, and
14 Enteroviruses in Chronic Fatigue Syndrome: Is There Evidence of Activation of a Nonspecific Polyclonal Immune
Response?
Some
long-term sequelae of Coxsackie B virus infection
Sporadic
myalgic encephalomyelitis in a rural practice
Studies
on enterovirus in patients with chronic fatigue syndrome
The
postviral fatigue syndrome--an analysis of the findings in 50 cases
There
is evidence for persistent enterovirus infections in chronic medical conditions in humans
There
is no evidence for persistent enterovirus infections in chronic medical conditions in humans
Viral
Isolation from Brain in Myalgic Encephalomyelitis (A Case Report)
Viruses
and Chronic Fatigue Syndrome
VP-1
antigen in chronic postviral fatigue syndrome
Studies by Dr John Chia focusing on the role of enterovirus in ME/CFS
Acute enterovirus infection followed by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and viral persistence
Chronic Enterovirus Infection in a Patient With Myalgic Encephalomyelitis: Chronic Fatigue Syndrome (ME/CFS) - Clinical, Virologic and Pathological Analysis
Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach
Diverse Etiologies for Chronic Fatigue Syndrome
Ribavirin and Interferon-α for the Treatment of Patients with Chronic Fatigue Syndrome Associated with Persistent Coxsackievirus B Infection: A Preliminary Observation
The role of enterovirus in chronic fatigue syndrome
Studies by Dr A Martin Lerner focusing on the role of herpesvirus in ME/CFS
A paradigm linking herpesvirus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome
A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome- improvement in left ventricular function
A Small, Randomized, Placebo-Controlled Trial of the Use of Antiviral Therapy for Patients with Chronic Fatigue Syndrome
A unified theory of the cause of chronic fatigue syndrome
Abnormal left ventricular myocardial dynamics in eleven patients with chronic fatigue syndrome
Abortive lytic Epstein–Barr virus replication in tonsil-B lymphocytes in infectious mononucleosis and a subset of the chronic fatigue syndrome
An update on the management of glandular fever (infectious mononucleosis) and its sequelae caused by Epstein–Barr virus (HHV-4)- new and emerging treatment strategies
Cardiac Involvement in Patients with Chronic Fatigue Syndrome as Documented with Holter and Biopsy Data in Birmingham, Michigan, 1991-1993
Editorial response- microbial persistence and idiopathic dilated cardiomyopathy
IgM Serum Antibodies to Epstein-Barr Virus are Uniquely Present in a Subset of Patients with the Chronic Fatigue Syndrome
IgM serum antibodies to human cytomegalovirus nonstructural gene products p52 and CM2(UL44 and UL57) are uniquely present in a subset of patients with chronic fatigue syndrome
Immunoassay with cytomegalovirus early antigens from gene products p52 and CM2 (UL44 and UL57) detects active infection in patients with chronic fatigue syndrome
New Cardiomyopathy- Pilot Study of Intravenous Ganciclovir in a Subset of the Chronic Fatigue Syndrome
PATENT- Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome
Prevalence of Abnormal Cardiac Wall Motion in the Cardiomyopathy Associated with Incomplete Multiplication of Epstein-Barr Virus and/or Cytomegalovirus in Patients with Chronic Fatigue Syndrome
Repetitively negative changing T-waves at 24-h electrocardiographic monitors in patients with the chronic fatigue syndrome (left ventricular dysfunction in a cohort)
Subset-directed antiviral treatment of 142 herpesvirus patients with chronic fatigue syndrome
Valacyclovir Treatment in Epstein-Barr Virus Subset Chronic Fatigue Syndrome- Thirty-six Months Follow-up
Validation of the Energy Index Point Score to Serially Measure the Degree of Disability in Patients with Chronic Fatigue Syndrome
Studies by Prof Jose Montoya et al focusing on the role of herpesvirus in ME/CFS
Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction
Randomized Clinical Trial to Evaluate the Efficacy and Safety of Valganciclovir in a Subset of Patients With Chronic Fatigue Syndrome
Response to Valganciclovir in Chronic Fatigue Syndrome Patients With Human Herpesvirus 6 and Epstein–Barr Virus IgG Antibody Titers
Severe Encephalomyelitis in an Immunocompetent Adult with Chromosomally Integrated Human Herpesvirus 6 and Clinical Response to Treatment with Foscarnet plus Ganciclovir
Use of valganciclovir in patients with elevated antibody titers against Human Herpesvirus-6 (HHV-6) and Epstein−Barr Virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue